International STD Research & Reviews <p style="text-align: justify;"><strong>International STD Research &amp; Reviews (2347-5196)</strong> aims to publish high-quality papers (<a href="/index.php/I-SRR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of ‘Sexually Transmitted Disease related research’. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> SCIENCEDOMAIN international en-US International STD Research & Reviews 2347-5196 Azole Resistance and Detection of the ERG11 Gene in Clinical Candida albicans Isolated from Pregnant Women with Vulvovaginitis Attending Federal Medical Centre, Yenagoa, Nigeria <p><strong>Introduction:</strong> <em>Candida albicans</em> is one of the most important aetiological agents causing vaginal candidiasis in pregnant women. Most women will experience at least one episode during their reproductive years. Antifungal resistance is a particular problem with Candida infections. Some types of Candida are increasingly resistant to the first-line and second-line antifungal medications.</p> <p><strong>Objective:</strong> To investigate the azole susceptibility of <em>Candida albicans</em> (<em>C. albicans</em>) from pregnant vulvovaginal candidiasis patients and to detect <em>ERG11</em> gene in these azole resistance isolates.</p> <p><strong>Methods:</strong> Forty-one clinical isolates of <em>C</em>. <em>albicans</em> were collected. Azole susceptibility was tested <em>in vitro</em> using microdilution techniques. The <em>ERG11</em> genes of 27 isolates of <em>C. albicans</em> (All resistant to azoles) were amplified using PCR method.</p> <p><strong>Results:</strong> Of the 67 isolates recovered, 41(61.19%) were <em>C. albicans</em>, of which 27 (65.85%) each, and 25(60.98%) were resistant to Fluconazole, Voriconazole, and Nystatin respectively. In total, <em>ERG11</em> genes were detected among 24(88.89%) of 27 <em>C. albicans</em> azole resistant isolates.</p> <p><strong>Conclusions:</strong> Twenty four <em>ERG11</em> genes were detected among 27 azole resistant <em>C. albicans</em> isolates, which indicates a possible relation with the increase in resistance to azole drugs and the recurrence of vulvovaginal candidiasis.</p> Abdulrasheed B. Abdu Tolulope Alade Catherine Omotu ##submission.copyrightStatement## 2019-09-03 2019-09-03 1 11 10.9734/ISRR/2019/v8i230097