International STD Research & Reviews <p style="text-align: justify;"><strong>International STD Research &amp; Reviews (ISSN:&nbsp;2347-5196)</strong> aims to publish high-quality papers (<a href="/index.php/I-SRR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of ‘Sexually Transmitted Disease related research’. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US (International STD Research & Reviews) (International STD Research & Reviews) Wed, 04 Aug 2021 12:30:08 +0000 OJS 60 Seroprevalence of Chlamydia trachomatis IgA, IgM and IgG Antibodies and Associated Risk Factors among Sexually Active Individuals at Saint Vincent de Paul Hospital in Dschang, West Cameroon <p><strong>Background:</strong><em> Chlamydia trachomatis</em> is the most common cause of sexually transmitted infections worldwide. Infections caused by this pathogen are usually symptomatic in men and asymptomatic in about 2/3 of women resulting in a variety of clinical complications.</p> <p><strong>Aim:</strong> To determine the seroprevalence of immunological markers and the risk factors associated with the seropositivity to <em>C. trachomatis</em> infection in sexually active individuals visiting the Saint Vincent de Paul Hospital in Dschang, West region Cameroon</p> <p><strong>Study Design:</strong> This was an analytical cross-sectional study conducted between July and September 2020 at Saint Vincent de Paul Hospital in Dschang, Cameroon.</p> <p><strong>Methods:</strong> A total of 154 participants were recruited during the data collection period. An indirect ELISA method was used to analyse participant’s serum samples. Risk factors were assessed through univariate and multivariate logistic regression using SPSS 25.</p> <p><strong>Results:</strong> The seroprevalence of <em>C. trachomatis</em> infection was 38.3% (95%CI: 30.6 - 46.0). Only 39.6% (95%CI: 31.6 - 47.3) of the study population had never been in contact with the bacterium. The reinfection rate among participants was 8.4% (95%CI: 4.0 - 12.8). Results revealed that being Male is a protective factor against the infection [<em>aOR</em>: 0.12; <em>95% CI</em>: 0.03 - 0.56; <em>P </em><em>꞊</em> .007]. The non-use of condom [<em>aOR</em>: 21.58<em>; 95% CI</em>: 3.53 – 132.06; <em>P </em><em>꞊</em> .001] and having encountered three or more sexual partners [<em>aOR</em>: 9.90; <em>95%CI</em>: 1.07 – 91.60; <em>P </em><em>꞊</em> .043] were the significant predictors of <em>Chlamydia</em> seropositivity.</p> <p><strong>Conclusion:</strong> The implementation of proactive strategies to curb down the spread of the infection is necessary in this locality. This can be done by providing NAATs to as many health facilities as possible, educating the population and standardizing treatment protocols.</p> Thomas Djifack Tadongfack, Irina Lydia Sudeu Nitcheu, Rodrigue Ngoune, Vanessa Rosine Nkouayep, Aline Camerl Nzeffouo Selabi, Viany Nankeng Manhafo, Blanche Lydie Bebe Moussango Enangue, Romeo Hervis Tedjieu, Carine Tsoplifak Kenfack, François Roger Nguepy Keubo, Monique Odette Kamtchueng, Michael Junior Piameu Chadou ##submission.copyrightStatement## Thu, 05 Aug 2021 00:00:00 +0000 Genetic Diversity of HIV-1 and Transfusion Safety : Systematic Review and Concepts Analysis <p><strong>Background</strong>: The genetic diversity of human immunodeficiency virus type 1 (HIV-1) is a real problem facing blood banks. This genetic diversity has a negative impact on diagnostic strategies within the transfusion chain by weakening the security of the donation. The objective of this study is to clarify the concepts emanating from the research project entitled : «Genetic diversity of HIV-1 and its effect on the residual risk in blood transfusion in Gabon».</p> <p><strong>Methods: </strong>This study was the result of a systematic review and a conceptual analysis of several studies that were systematically searched for in databases (PubMed, Google Scholar, and Medline), and whose object was focused on the genetic diversity of HIV -1 and its impact on transfusion safety. Indeed, the information relating to the concepts coming from the full articles was used. These were obtained by reading the most relevant articles. All relevant studies reporting data on HIV-1 genetic diversity and blood safety published in English between January 2012 and December 2020 have been identified for context. The method of conceptual analysis of «&nbsp;Walker and Avant (2005)&nbsp;» was used to clarify the different concepts of our study. The correlation test was used to show the relationship between the concepts.</p> <p><strong>Results: </strong>This systematic review and conceptual analysis study made it possible to determine the variables and to clarify the different concepts (HIV-1, Genetic diversity, Blood transfusion, Residual risk) essential for carrying out our research project entitled: "Genetic diversity of HIV-1 and its effect on the residual risk in blood transfusion". This model made it possible to show the effect of the genetic diversity of HIV-1 on the residual risk in blood transfusion using as model variables : viral load and serological markers (Antibodies and P24 Antigen). Knowledge of molecular strains (URF, CRF, subtypes) during this study made it possible to better identify the molecular strains most involved in the residual risk. Despite its complexity, this conceptual analysis contributed enormously to the understanding of the activities and the quantifiable and non-quantifiable components that participated in our study. Statistical analysis showed that the HIV-1 concept was significantly related to the other three concepts with <em>P = 0.001</em>. Likewise for the concept of genetic diversity was also significantly linked to the two other concepts with <em>P = 0.003</em>.</p> <p><strong>Conclusion</strong>: The genetic diversity of HIV-1 in the blood transfusion environment contributes significantly to the transmission of HIV from donor to recipient. The mastery of these molecular strains is essential for the various blood banks to ensure a safe blood supply.</p> Christian Mangala, Joseph Fokam, Denis Maulot Bangola, Thérèse Nkoa ##submission.copyrightStatement## Wed, 04 Aug 2021 12:30:53 +0000